文獻名： Engineering Lysosome-Targeting BODIPY Nanoparticles for Photoacoustic Imaging and Photodynamic Therapy under Near-Infrared Light
作者： Wenbo Hu†, Hengheng Ma†, Bing Hou†, Hui Zhao†, Yu Ji†, Rongcui Jiang†, Xiaoming Hu†, Xiaomei Lu‡, Lei Zhang†, Yufu Tang†, Quli Fan†, and Wei Huang‡
† Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, Nanjing 210023, China
‡ Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech), Nanjing 211816, China
摘要：Developing lysosome-targeting organic nanoparticles combined with photoacoustic imaging (PAI) and photodynamic therapy (PDT) functions toward personalized medicine are highly desired yet challenging. Here, for the first time, lysosome-targeting BODIPY nanoparticles were engineered by encapsulating near-infrared (NIR) absorbed BODIPY dye within amphiphilic DSPE-mPEG5000 for high-performing lysosomal PAI and acid-activatable PDT against cancer cells under NIR light.
關鍵詞：lysosome-targeting; near-infrared absorption; photoacoustic imaging; photodynamic therapy; theranostic nanoparticleslysosome-targeting; near-infrared absorption; photoacoustic imaging; photodynamic therapy; theranostic nanoparticles
